Topographical frequency dynamics within EEG and MEG sleep spindles
Summary
The study investigates how the frequency and location of sleep spindles change over their brief duration during stage 2 sleep. We found that spindles typically evolve from a faster, posterior-central pattern to a slower, anterior-frontal pattern, a dynamic that is clearly visible in EEG and present to a lesser extent in MEG.
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@article{Dehghani_spindleTopo_2011,
title = {Topographical frequency dynamics within EEG and MEG sleep spindles},
journal = {Clinical Neurophysiology},
volume = {122},
number = {2},
pages = {229-235},
year = {2011},
issn = {1388-2457},
doi = {https://doi.org/10.1016/j.clinph.2010.06.018},
url = {https://www.sciencedirect.com/science/article/pii/S1388245710005432},
author = {Nima Dehghani and Sydney S. Cash and Eric Halgren},
keywords = {Spindle, Synchrony, MEG, EEG, Cortex, Thalamus, Inverse solution},
}
Code & Data
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Abstract
Spindles are rhythmic bursts of 10–16 Hz activity, lasting ∼1 s, occur during normal stage 2 sleep. Spindles are slower in frontal EEG and possibly MEG. The posterior-fast EEG pattern may predominate early in the spindle, and the anterior-slow pattern late. We aimed to determine the proportion of spindles showing this spatio-spectro-temporal interaction for EEG, and whether it occurs in MEG.
We recorded high density EEG and MEG from seven healthy subjects during normal stage 2 sleep. High vs. low frequency (12 vs. 14 Hz) power was measured early vs. late (25th–45th vs. 55th–75th duration percentile) in 183 spindle discharges.
The predicted spatio-spectro-temporal interaction was shown by 48% of EEG and 34% of MEG spindles (chance = 25%). Topographically, high frequency EEG power was greatest at midline central contacts, and low frequency power at midline frontal. This frequency-specific topography was fixed over the course of the spindle.
An evolution from posterior-fast to anterior-slow generators commonly occurs during spindles, and this is visible with EEG and to a lesser extent, MEG.
The spatio-spectral-temporal evolution of spindles may reflect their possible involvement in coordinating cortical activity during consolidation.
Citing
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